The Bio Busters
Episode 16 - Beyond Antibiotics: Phage Therapy

Episode 16 - Beyond Antibiotics: Phage Therapy

August 7, 2019

Show notes:

In the show, The Bio Busters professors, Dr. A and Dr. C, discuss phages, their life cycles, applications (both industrial and therapeutic), potential drawbacks, and future directions. Keep the discussion and comments going on the iTunes review section, or feel free to e-mail the podcast with future show ideas and thoughts on the current show.

Music by Bahaa Naamani

Email us at thebiobusters@gmail.com

References:

Cell Host Microbe. 2019 Feb 13;25(2):219-232. doi: 10.1016/j.chom.2019.01.014.

Phage Therapy: A Renewed Approach to Combat Antibiotic-Resistant Bacteria.

Kortright KE1, Chan BK2, Koff JL3, Turner PE4.

Science. 2019 Mar 29;363(6434). pii: eaat9691. doi: 10.1126/science.aat9691.

Bacteriophage trigger antiviral immunity and prevent clearance of bacterial infection.

Sweere JM1,2, Van Belleghem JD1, Ishak H1,3, Bach MS1, Popescu M1,2, Sunkari V1, Kaber G1, Manasherob R1, Suh GA1, Cao X1, de Vries CR1, Lam DN1, Marshall PL1,2, Birukova M1,2, Katznelson E1, Lazzareschi DV1, Balaji S4, Keswani SG4, Hawn TR5, Secor PR6, Bollyky PL7.

 

Viruses. 2018 Apr; 10(4): 205.

Published online 2018 Apr 19. doi: 10.3390/v10040205

Bacteriophage Applications for Food Production and Processing

Zachary D. Moye,* Joelle Woolston, and Alexander Sulakvelidze

https://www.sciencedaily.com/terms/antibiotic_resistance.htm

https://www.forbes.com/sites/quora/2018/03/28/why-bacteriophage-therapy-wont-solve-the-problem-of-antibiotic-resistance/#5c26f92fbf3f

Episode 15 - DNA testing

Episode 15 - DNA testing

July 19, 2019

Show notes:

In the show, The Bio Busters professors, Dr. A and Dr. C, discuss the concept of genetic testing as it relates to ancestry. The docs discuss the foundational concepts of how DNA testing works and what exactly these tests are purported to measure. Additionally, they compare the pros and cons of three major types of ancestry tests, as well as what you should expect/not expect when using each of these tests. Keep the discussion and comments going on the iTunes review section, or feel free to e-mail the podcast with future show ideas and thoughts on the current show.

 

Music by Bahaa Naamani

Email us at thebiobusters@gmail.com

References:

https://www.sciencenews.org/article/review-genetic-tests-23andme-veritas-genos-health-comparison

https://www.livescience.com/62690-how-dna-ancestry-23andme-tests-work.html

Link to Robert Hooke’s Micrographia

http://www.gutenberg.org/files/15491/15491-h/15491-h.htm#obsLIII

Episode 14 - War on Science

Episode 14 - War on Science

May 10, 2019

Show notes:

In the show, The Bio Busters professors, Dr. A and Dr. C, discuss the current science climate and the war on science. Keep the discussion and comments going on the iTunes review section, or feel free to e-mail the podcast with future show ideas and thoughts on the current show.

Music by Bahaa Naamani

Email us at thebiobusters@gmail.com

References:

https://www.scientificamerican.com/article/is-there-really-a-war-on-science/

http://inthesetimes.com/article/21640/donald-trump-climate-science-interior-department-ryan-zinke-global-warming

https://allianceforscience.cornell.edu/blog/2018/08/opinion-russian-campaign-spread-anti-vaccine-myths-part-wider-war-science-truth/

David A. Broniatowski, Amelia M. Jamison, SiHua Qi, Lulwah AlKulaib, Tao Chen, Adrian Benton, Sandra C. Quinn, and Mark Dredze, 2018:

Weaponized Health Communication: Twitter Bots and Russian Trolls Amplify the Vaccine Debate

American Journal of Public Health 108, 1378_1384,https://doi.org/10.2105/AJPH.2018.304567

Episode 13 - Thiel Research Day

Episode 13 - Thiel Research Day

April 16, 2019

Show notes:

In the show, The Bio Busters professors, Dr. A and Dr. C, discuss Thiel College’s Annual Scholarship and Arts Symposium and some of the posters presented. The docs also record on-site interviews with some of the students. Keep the discussion and comments going on the iTunes review section, or feel free to e-mail the podcast with future show ideas and thoughts on the current show.

Music by Bahaa Naamani

Email us at thebiobusters@gmail.com

Episode 12 - Chat with Dr. Thomas Newpher

Episode 12 - Chat with Dr. Thomas Newpher

March 19, 2019

Show notes:

In the show, The Bio Busters professors, Dr. A and Dr. C, discuss with Dr. Thomas Newpher his path to becoming a professor at Duke University. Dr. Newpher graduated from Thiel College in 2000 and now works at Duke University. His website can be found below. Keep the discussion and comments going on the iTunes review section, or feel free to e-mail the podcast with future show ideas and thoughts on the current show.

Music by Bahaa Naamani

Email us at thebiobusters@gmail.com

References:

https://dibs.duke.edu/scholars/thomas-newpher

Episode 11- Inflammatory Bowel Diseases

Episode 11- Inflammatory Bowel Diseases

March 13, 2019

Show notes:

In the show, The Bio Busters professors, Dr. A and Dr. C, discuss inflammatory bowel diseases. The professors discuss Crohn’s disease and ulcerative colitis, focusing on etiology, symptoms and signs, as well as treatments and therapy (conventional and unconventional). Keep the discussion and comments going on the iTunes review section, or feel free to e-mail the podcast with future show ideas and thoughts on the current show.

Music by Bahaa Naamani

Email us at thebiobusters@gmail.com

 

References:

http://www.crohnscolitisfoundation.org/what-are-crohns-and-colitis/what-is-ulcerative-colitis/

Norman JM et al.. Disease-specific alterations in the enteric virome in inflammatory bowel disease. Cell. 2015

Mahesh Gajendran et al. A comprehensive review and update on ulcerative colitis. Disease-a-Month. 2019

Basso Paulo José et al. Microbial-Based Therapies in the Treatment of Inflammatory Bowel Disease – An Overview of Human Studies. Frontiers in Pharmacology. 2019

Eichenberger RM et al. Hookworm Secreted Extracellular Vesicles Interact With Host Cells and Prevent Inducible Colitis in Mice. Frontiers in Immunology. 2018

Liu Y et al. Schistosoma japonicum attenuates dextran sodium sulfate-induced colitis in mice via reduction of endoplasmic reticulum stress. World Journal of Gastroenterology. 2017

Summers RW et al. Trichuris suis seems to be safe and possibly effective in the treatment of inflammatory bowel disease. Am J Gastroenterol. 2003

Summers RW et al. Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. Gastroenterology. 2005

Episode 10 - Becoming a Scientist

Episode 10 - Becoming a Scientist

February 5, 2019

Show notes:

In the show, The Bio Busters professors, Dr. A and Dr. C, host Dr. Sarah Woodley, Associate Professor of Biological Sciences at the Bayer School of Natural and Environmental Sciences, Department of Biological Sciences at Duquesne University in Pittsburgh, Pennsylvania. The Drs. discuss Dr. Woodley’s career path and her advice to those entering science or wanting to become scientists. Dr. Woodley also discusses research opportunities at Duquesne University. The Drs. also discuss the importance of science outreach. Keep the discussion and comments going on the iTunes review section, or feel free to e-mail the podcast with future show ideas and thoughts on the current show.

Music by Bahaa Naamani

Email us at thebiobusters@gmail.com

 

Links:

Dr. Woodley’s Duquesne’s info:

https://www.duq.edu/academics/faculty/sarah-woodley

If you are interested in Duquesne’s University REU program, please apply here:

https://www.duq.edu/biologycircle

Episode 9 - Cancer Immunotherapy

Episode 9 - Cancer Immunotherapy

January 18, 2019

Show notes:

In the show, The BioBusters professors, Dr. A and Dr. C, discuss the science behind the 2018 Nobel Prize in Physiology or Medicine. The BioBusters Docs discuss checkpoint control in immune responses, as well as activating and inhibitory receptors on T cells. The Docs discuss the various FDA approved checkpoint inhibitor drugs and the cancers they treat. Keep the discussion and comments going on the iTunes review section, or feel free to e-mail the podcast with future show ideas and thoughts on the current show.

Music by Bahaa Naamani

Email us at thebiobusters@gmail.com

 

References:

Freeman, G.J., Long, A.J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L.J., Malenkovich, N., Okazaki, T., Byrne, M.C., Horton, H.F., Fouser, L., Carter, L., Ling, V., Bowman, M.R., Carreno, B.M., Collins, M., Wood, C.R. & Honjo, T. (2000). Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med, 192(7), 1027–1034.

Hodi, F.S., Mihm, M.C., Soiffer, R.J., Haluska, F.G., Butler, M., Seiden, M.V., Davis, T., Henry-Spires, R., MacRae, S., Willman, A., Padera, R., Jaklitsch, M.T., Shankar, S., Chen, T.C., Korman, A., Allison, J.P. & Dranoff, G. (2003). Biologic activity of cytotoxic T lymphocyte-associated antigen 4 antibody blockade in previously vaccinated metastatic melanoma and ovarian carcinoma patients. Proc Natl Acad Sci USA, 100(8), 4712-4717

https://www.nobelprize.org/prizes/medicine/2018/press-release/

https://blog.dana-farber.org/insight/2015/09/what-is-a-checkpoint-inhibitor/

https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/immune-checkpoint-inhibitors.html

https://www.science.org.au/curious/people-medicine/releasing-immune-systems-brakes-fight-cancer

https://www.wired.com/story/cancer-immunotherapy-has-arrived-but-not-for-everyone/

https://www.sciencedaily.com/releases/2018/10/181009102517.htm

Episode 8 - Gene Therapy

Episode 8 - Gene Therapy

December 11, 2018

Show notes:

In the show, The Bio Busters professors, Dr. A and Dr. C, discuss with Philosophy professor Dr. Morgan the history of recombinant DNA and gene therapy. The professors also discuss CRISPR editing technology, as well as ethical and societal implications of these technologies, among many other musings. Keep the discussion and comments going on the iTunes review section, or feel free to e-mail the podcast with future show ideas and thoughts on the current show.

 

Music by Bahaa Naamani

Email us at thebiobusters@gmail.com

 

References:

https://www.mayoclinic.org/tests-procedures/gene-therapy/about/pac-20384619

https://ghr.nlm.nih.gov/primer/therapy/safety

https://www.genome.gov/10004764/

https://ghr.nlm.nih.gov/primer/therapy/ethics

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3586794/

Episode 7 - Musings on the Origins of Life

Episode 7 - Musings on the Origins of Life

November 15, 2018

Show notes:

In the show, The Bio Busters professors, Dr. A and Dr. C, discuss with Biology Senior TJ Fisher the mysteries of life and how it could have started in the early days of our planet. The professors discuss abiogenesis, the Miller-Urey experiment, and the RNA world hypothesis among many other musings. Keep the discussion and comments going on the iTunes review section, or feel free to e-mail the podcast with future show ideas and thoughts on the current show.

 

Music by Bahaa Naamani

Email us at thebiobusters@gmail.com

 

References:

“Exploring Life’s Origins: Ribozymes & the RNA World.” Accessed November 14, 2018. http://exploringorigins.org/ribozymes.html.

Miller, Stanley L. “A Production of Amino Acids Under Possible Primitive Earth Conditions.” Science 117, no. 3046 (May 15, 1953): 528–29. https://doi.org/10.1126/science.117.3046.528.

Nasir, Arshan, and Gustavo Caetano-Anollés. “A Phylogenomic Data-Driven Exploration of Viral Origins and Evolution.” Science Advances 1, no. 8 (September 1, 2015): e1500527. https://doi.org/10.1126/sciadv.1500527.

Richter, Viviane. “What Came First, Cells or Viruses?” Cosmos Magazine. Accessed November 14, 2018. https://cosmosmagazine.com/biology/what-came-first-cells-or-viruses.

“Spontaneous Generation | Microbiology.” Accessed November 14, 2018. https://courses.lumenlearning.com/microbiology/chapter/spontaneous-generation/.